Amino Acids, Plasma


Abbrev Code:AA1, AA25, AA   
Order Code:LAB811, LAB3256, LAB3255Order Name:Amino Acids Plasma Quantitative
Order Instructions:If a single amino acid is requested, order AA1 (LAB811) and specify the amino acid required; otherwise, order AA (LAB3255). If 2-5 amino acids are requested, order with AA25 (LAB8256) and specify the amino acids required.
Synonyms:Aminogram; AA; Alanine; B-alanine; A-aminoadipic Acid; B-aminoisobutyric Acid; Anserine; Arginine; Argininosuccinic Acid; Asparagine; Aspartic Acid; Carnosine; Citrulline; Half-cystine; Cystathionine; Glutamic Acid; Glutamine; Glycine; Histidine; Homocystine; Hydroxylysine; Hydroxyproline; Isoleucine; Leucine; Lysine; Methionine; 1-methylhistidine; 3-methylhistidine; Ornithine; Phenylalanine; Proline; Sarcosine; Serine; Taurine; Threonine; Tyrosine; Valine; Homocitaulline
Methodology:High performance ion exchange liquid chromatography
CPT Codes: 82131 x1, 82136 x1, 82139 x1
Test Includes:Alanine, B-alanine, A-aminoadipic acid, B-aminoisobutyric acid, anserine, arginine, argininosuccinic acid, asparagine, aspartic acid, carnosine, citrulline, half-cystine, cystathionine, glutamic acid, glutamine, glycine, histidine, homocystine, hydroxylysine, hydroxyproline, isoleucine, leucine, lysine, methionine, 1-methylhistidine, 3-methylhistidine, ornithine, phenylalanine, proline, sarcosine, serine, taurine, threonine, tyrosine, valine.
Turnaround Time:Performed Mon-Fri; results are reported the next day.
Special Instructions:Provide clinical history and specify amino acid(s) desired on request form.


Collection Instructions

Specimen:Blood
Optimal Volume:2 mL
Minimum\Peds Volume:0.7 mL
Container:Green (sodium heparin, no gel)
Alternate Containers: Green (lithium heparin, no gel), Green (lithium heparin, gel), Purple (EDTA)
Causes for Rejection:Sample not separated from cells and frozen within 2 hours of collection


Processing and Shipping

Specimen Processing:Within 2 hours, centrifuge and aliquot 1 mL, 0.3 mL minimum. Room temperature or refrigerated samples must arrive at Biochemical Genetics within 2 hours of collection (preferred). Alternately, store specimen in the freezer and ship on ice.
Shipping Instructions:Ship on dry ice.
Test Performed at or Referral Lab UM Special Drug/Biochemical Genetics (Y)  (UMMC East Bank)


Interpretive

Reference Range:An interpretation of the report can be ordered/requested.
  0-4 mo
umol/dL		 4 mo-12 y
umol/dL		  > 12 y
umol/dL
Alanine 0-61 10-80 22-62
A-aminoadipic acid   0-2 0-6
A-aminobutyric acid   0-5 0-8
Arginine 0-25 1-11 2-18
Asparagine 0-15 0-11 1-5
Aspartic Acid 0-3 0-3 0-4
Citrulline 0.7-4.1 1.0-5.0 1.3-6.0
Half-Cystine 0-14 2-12 3-15
Glutamic Acid 0-20 0-14 0-16
Glutamine 0-93 5-74 41-86
Glycine 0-57 9-48 13-50
Histidine 0-14 4-13 3-15
Hydroxyproline 0-9 0-4 0-3
Isoleucine 0-11 2-13 4-11
Leucine 0-18 4-24 8-21
Lysine 0-26 0-25 6-26
Methionine 0-6 1-5 1-6
1-methylhistidine   0-2 0-2
3-methylhistidine   0-3 0-1
Ornithine 0-16 1-11 2-16
Phenylalanine 0-12 1-8 3-10
Phosphoserine     1-7
Proline 0-43 7-41 0-48
Serine 0-30 0-22 4-18
Taurine 0-23 0-17 7-32
Threonine 0-24 0-18 5-25
Tyrosine 0-15 2-9 4-13
Valine 0-29 0-39 8-46
 
Use:Elevations or abnormalities in plasma amino acids are characteristic of urea cycle disorders, phenylketonuria, maple syrup urine disease, HHH syndrome, hyperglycinemia and other aminoacidopathies. Also used to monitor nutritional support.


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