Bone Marrow Aspirate and Trephine Biopsy, Morphology

Abbrev Code:CBM   
Order Code:LAB6  
Synonyms:Biopsy, Bone Marrow Aspirate/Trephine; Trephine Biopsy
CPT Codes: 85097 x1, 85097-26 x1, 88305 x1, 8830526-26 x1, 85060 x1, 85097 x1, 88305-26 x1
Test Includes:Examination of bone marrow aspirate, trephine biopsy and peripheral blood smears.
Turnaround Time:Preliminary results are available in 24-36 hours. Final results are reported within 72 hours.

Collection Instructions

Specimen:Bone marrow and peripheral blood.
Container:Purple (EDTA), Microscope slides
Collection Instructions:
  • When bone marrow has been processed: Provide 4-8 unstained direct smears, 8 unstained bone marrow concentrate smears and 4-6 unstained peripheral blood smears (prepared from fresh [less than 4 hours after collection] blood.
  • When bone marrow has not been processed: Provide one 5 mL bone marrow aspirate in EDTA, 4-8 unstained direct aspirate smears, 4-6 unstained peripheral blood smears (prepared from fresh [less than 4 hours after collection] blood, unstained biopsy touch imprints, and bone marrow core (trephine) biopsy submitted in a container of AZF fixative.

Processing and Shipping

Specimen Processing:Store at room temperature.
Shipping Instructions:Ship slides in protective slide holder(s) and bone marrow aspirate(s) in a tightly sealed container at room temperature. Bone marrow core (trephine) biopsy submitted in a container of fixative that is tightly sealed must be sent in a separate sample transport bag at room temperature.
Test Performed at or Referral Lab UM Special Hematopathology (P)  (Lakes, Northland, Ridges, Southdale, UMMC East Bank)


Reference Range:Interpretive report by hematopathologist or pathologist.
Use:Evaluation of patients with suspected disorders of the hematopoietic system including all forms of leukemia, anemia, lymphoma, and myeloma. Also used for investigation of patients with metastatic malignancies. Nonmalignant disorders in which marrow biopsies are appropriate are suspected infectious processes (culture and examine for granulomas) and inherited metabolic disorders.

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