Creatinine Clearance

Abbrev Code:CRCL   
Order Code:LAB383Order Name:Creatinine Clearance
Order Instructions:Order UCRT. Enter collection volume, duration, height and weight.
CPT Codes: 82575 x1, 82575 x1, 81050 x1, 81050 x1
Test Includes:Urine creatinine, raw clearance and standard clearance
Turnaround Time:Performed and reported 24 hours/day.
Special Instructions:Blood creatinine must be collected.
  • If the blood creatinine is within the reference range, the blood and urine specimens must be collected within 72 hours of each other. 
  • If the blood creatinine is outside the reference range, the blood and urine specimens must be collected within 24 hours of each other. 

Record the patient's height and weight.
Associated Links:

Urine Collection Procedure, Roche Go Live Schedule

Collection Instructions

Specimen:Urine, timed collection (12 to 24 hour; 2-12 hour collections are acceptable but not recommended)
Optimal Volume:Submit entire collection; analysis requires 0.2 mL
Container:3 L plastic jug
Collection Instructions:
  • Refrigerate during collection.
  • Collection on ice preferred, but not required.
  • IVP dye does not interfere with sample analysis.
  • Acceptable preservatives: HCl, or boric acid.
Patient Preparation:The patient should continue good hydration and avoid cooked meat, coffee, tea, or drugs (especially cephalotoxin and other cephalosporins) throughout the collection period.
Causes for Rejection:No serum creatinine collected; collection not timed.  

Processing and Shipping

Specimen Processing:Mix collection well before aliquot is taken. Centrifuge specimens containing cells or precipitate. Aliquot 1 mL, 0.2 mL minimum. Store in refrigerator.
Shipping Instructions:Ship at refrigerated temperature.
Stability:Roche: 2 days at room temperature; 6 days refrigerated; 6 months frozen.
Test Performed at or Referral Lab Chemistry  (Roche-CSC Maple Grove, Roche-CSC Mpls, Roche-Grand Itasca, Roche-Lakes, Roche-Northland, Roche-Range, Roche-Ridges, Roche-Southdale, Roche-St. John's, Roche-UMMC East, Roche-UMMC West, Woodwinds)


Reference Range:
  Test Units Age Female Male
Abbott  Std
all 70-135 70-135
Vista Std
Clearance calibrated to IDMS
all 100-160 110-180
Abbott & Vista Creatinine, urine g/spec 0-2 y n/a n/a
Abbott & Vista Creatinine, urine g/spec 3-8 y 0.11-0.68 0.11-0.68
Abbott & Vista Creatinine, urine g/spec 9-12 y 0.17-1.41 0.17-1.41
Abbott & Vista Creatinine, urine g/spec 13-17 y 0.29-1.87 0.29-1.87
Abbott & Vista Creatinine, urine g/spec 18 & older 0.80-1.80 1.00-2.00
Roche Raw Clearance mL/min all 66-143 66-143
Roche Standard Clearance mL/min/
all 100-160 110-180
Roche Creatinine Urine g/spec all 0.72-1.51 0.98-2.20
*The calculation for standard creatinine clearance in mL/min =urine volume/minute x urine creatinine/serum creatinine x 1.73/surface area of body in m2. Body surface area is obtained using the DuBois formula (see below) which requires height and weight.
*BSA = 0.007184 x weight (kg) 0.425 x height (m) 0.725  
*Normal ranges for children less than one year of age are not well established. Ranges seem to be lower than those of older patients.   * SI Unit Conversion Factor: clearance (mL/min) x 0.01667 = clearance (mL/s)

Results should be inspected for consistency, assuming a normal collection should contain 1 g creat/24 hour.  
Use:Evaluate renal function.

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